Activity Test Of Ethanol Extract Of Java Wood Leaf (Lannea coromandalica (Houtt.) Merr) from Bone District On Streptozotocin Induced Diabetic Rats

Abstract

Antidiabetics are drugs or a class of drugs that have activity in reducing or reducing the increase in blood glucose levels. The purpose of this study was to determine the activity of Kayu Jawa (Lannea coromandalica (Houtt.) Merr) Leaf Ethanol Extract against Streptozotocin- induced Diabetic Rats (Rattus norvegicus). The simplicia powder of Java Wood Leaf was extracted by maceration using 70% ethanol and obtained an extract yield of 6.025%. Antidiabetic activity testing was carried out using a digital glucometer on white rats (Rattus norvegicus). A total of 15 individuals were divided into 5 treatment groups, each group consisting of 3 individuals. Group I was given 1% Na-CMC as a negative control, group II was given kayu jawa leaf extract at a dose of 200 mg/kg BW, group III was given java wood leaf extract at a dose of 300 mg/kg BW, group IV was given glibenclamide tablets as a positive control and group V given kayu jawa leaf extract at a dose of 400 mg/kg BW. Research data shows that the average percentage of decreased blood glucose levels is -0.43%, 26.27%, 44.22%, 50.83%, 59.25%. The results obtained can be concluded that java wood leaf extract with doses and doses of 200 mg/kg BW, 300 mg/kg BW and 400 mg/kg BW rats had no significantly different activity from the positive control (Glibenclamide) and a dose of 200 mg/kg BW , 300 mg/kg BW and 400 mg/kg BW have significantly different activity against negative control (Na-CMC 1%) in lowering blood glucose levels